George Church

A trailblazing biologist grapples with her role in the biggest scientific discovery of our era: a cheap, easy way of rewriting genetic code, with nearly limitless promise and peril. Not since the atomic bomb has a technology so alarmed its inventors that they warned the world about its use. Not, that is, until the spring of 2015, when biologist Jennifer Doudna called for a worldwide moratorium on the use of the new gene-editing tool CRISPR—a revolutionary new technology that she helped create—to make heritable changes in human embryos. The cheapest, simplest, most effective way of manipulating DNA ever known, CRISPR may well give us the cure to HIV, genetic diseases, and some cancers, and will help address the world’s hunger crisis. Yet even the tiniest changes to DNA could have myriad, unforeseeable consequences—to say nothing of the ethical and societal repercussions of intentionally mutating embryos to create “better” humans. Writing with fellow researcher Samuel Sternberg, Doudna shares the thrilling story of her discovery, and passionately argues that enormous responsibility comes with the ability to rewrite the code of life. With CRISPR, she shows, we have effectively taken control of evolution. What will we do with this unfathomable power?

Recent advances in genome editing tools using endonucleases such as TALENs, ZFNs, and CRISPRs, combined with genomic engineering technologies, have opened up a wide range of opportunities from applications in the basic sciences and disease biology research, to the potential for clinical applications and the development of new diagnostic tools. This complete guide to endonuclease-based genomic engineering gives readers a thorough understanding of this rapidly expanding field. Chapters cover the discovery, basic science, and application of these techniques, focusing particularly on their potential relevance to the treatment of cancer, and cardiovascular and immunological disease. The final section discusses the legal and ethical issues which accompany the technology. Providing authoritative coverage of the potential that genome editing and engineering have, this is an ideal reference for researchers and graduate students and those working in the biotechnology and pharmaceutical industries, as well as in a clinical setting.

The instant New York Times bestseller! A Wall Street Journal Best Science Book of the Year! A Popular Science Best Science Book of the Year! From a top scientist and the creator of the hugely popular web comic Saturday Morning Breakfast Cereal, a hilariously illustrated investigation into future technologies -- from how to fling a ship into deep space on the cheap to 3D organ printing What will the world of tomorrow be like? How does progress happen? And why do we not have a lunar colony already? What is the hold-up? In this smart and funny book, celebrated cartoonist Zach Weinersmith and noted researcher Dr. Kelly Weinersmith give us a snapshot of what's coming next -- from robot swarms to nuclear fusion powered-toasters. By weaving their own research, interviews with the scientists who are making these advances happen, and Zach's trademark comics, the Weinersmiths investigate why these technologies are needed, how they would work, and what is standing in their way. New technologies are almost never the work of isolated geniuses with a neat idea. A given future technology may need any number of intermediate technologies to develop first, and many of these critical advances may appear to be irrelevant when they are first discovered. The journey to progress is full of strange detours and blind alleys that tell us so much about the human mind and the march of civilization. To this end, Soonish investigates ten different emerging fields, from programmable matter to augmented reality, from space elevators to robotic construction, to show us the amazing world we will have, you know, soonish. Soonish is the perfect gift for science lovers for the holidays!

The Five Forces reveals how technology is unleashing forces that will forever alter our lives, politics, and society. Learn more about nanotechnology, transhumanism, the future of space exploration and colonization, super human computers, and so much more! Discover what lies in our future: How will humans change as we merge with our machines, embracing transhumanism?What happens when intelligent algorithms make all the decisions?Should we connect our brains directly to the Internet?And are we entering an age of simulated realities? The Five Forces takes you on a journey to see what the most brilliant minds of our age are dreaming up. Hoffman reveals how new scientific breakthroughs and business ventures are poised to reshape our lives and turn science fiction into fact. With scientists in Japan creating humanoid robots, Silicon Valley biohackers boosting their IQs, and Chinese labs developing human-monkey chimeras, Hoffman gives an inside look at the limits of what’s possible today and the impact these developments will have. Mass Connectivity What happens when brain chips connect our minds directly to the internet? Will we be able to boost our IQs, exchange memories, and communicate with our thoughts? Or will this turn into a nightmare, with corporations reading our minds, hackers overwriting our identities, and governments controlling our actions? Bio Convergence Now that we can decode the building blocks of life and create new lifeforms that never existed before, what comes next? Will we conquer disease, resurrect extinct species, develop superior plants and animals, create DNA-edited babies, and even spawn other intelligent beings? Human Expansionism Is it our manifest destiny to colonize Mars and extend the human race beyond the limits of our solar system? How will technologies like space travel, new materials, and nanotech transform our civilization and open up new horizons we never imagined possible? Deep Automation As our machines become capable enough to do every job better, faster, and cheaper, how will this affect society? Will we wind up delegating our most important decisions to data crunching algorithms? And does this mean our machines will end up running our economies, our corporations, and even our lives? Intelligence Explosion As soon as we create a superintelligence that far surpasses human capabilities, what will happen to us? Will we be able to control our machines, or will they eventually control us? Are we headed for a paradise of plenty, where our technology eliminates hunger, disease, poverty, and war? Or will this be the end of our reign as the rulers of the planet?